There is no approved vaccine or treatment against SARS-CoV-2, and the available interventions-including country lockdowns and social distancing-have severely disrupted the global supply chain and economy.ДЄ suitable animal model is essential for understanding the pathogenesis of this disease and for evaluating vaccine and therapeutic candidates. The clinical spectrum of patients with coronavirus diseaseВ 2019 (COVID-19) is wide 19% of 44,415В confirmed patients in China progressed to severe and critical illness 5, with an estimated 1.4% case fatality risk in symptomatic cases 6. Although 55% of the initial cases were linked to one seafood wholesale market at which wild animals were also sold 3, multiple viral (sustained human-to-human transmissibility by symptomatic and pre-symptomatic individuals 4) and ecological (extensive domestic and international travel during Chinese Lunar New Year) factors have contributed to the rapid global spread of the virus. SARS-CoV-2 was first detected from a cluster of patients with pneumonia in Wuhan (Hubei province, China) in December 2019. Our results suggest that features associated with SARS-CoV-2 infection in golden hamsters resemble those found in humans with mild SARS-CoV-2 infections. Inoculated and naturally infected hamsters showed apparent weight loss on days 6вЂ“7В post-inoculation or post-contact all hamsters returned to their original weight within 14В days and developed neutralizing antibodies. Although viral RNA was continuously detected in the nasal washes of inoculated hamsters for 14В days, the communicable period was short and correlated with the detection of infectious virus but not viral RNA. Transmission via fomites in soiled cages was not as efficient. Notably, SARS-CoV-2 was transmitted efficiently from inoculated hamsters to naive hamsters by direct contact and via aerosols. We also found viral antigens in epithelial cells of the duodenum, and detected viral RNA in faeces. Immunohistochemistry assay demonstrated the presence of viral antigens in nasal mucosa, bronchial epithelial cells and areas of lung consolidation on daysВ 2 and 5 after inoculation with SARS-CoV-2, followed by rapid viral clearance and pneumocyte hyperplasia at 7В days after inoculation.

Here we report the pathogenesis and transmissibility of SARS-CoV-2 in golden (Syrian) hamsters ( Mesocricetus auratus). A suitable small animal model is needed to support the development of vaccines and therapies. Severe acute respiratory syndrome coronavirusВ 2 (SARS-CoV-2), a novel coronavirus with high nucleotide identity to SARS-CoV and to SARS-related coronaviruses that have been detected in horseshoe bats, has spread across the world and had a global effect on healthcare systems and economies 1, 2.

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